Dr. Miles is Co-Director of the Institute of Behavioral and Neural Sciences at the University of St. Andrews and partner member of the Euan MacDonald Centre for Motor Neurone Disease Research at the University of Edinburgh in the UK."My lab investigates how motor neurons affected by ALS lose the ability to generate the electrical signals required to make muscles contract due to changes in specialised proteins called ion channels. This work highlights new targets that could lead to new treatments for ALS."
A.C. Devlin, K. Burr, S. Borooah, J. D. Foster, E. M. Cleary, I. Geti, L. Vallier, C. E. Shaw, S. Chandran and G. B. Miles (2015). Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability. Nature Communications, 6:5999 doi:10.1038/ncomms6999