Showing posts with label Biology. Show all posts
Showing posts with label Biology. Show all posts

Wednesday, 11 October 2017

Biology Professor wins Book Award

This month, Professor Kevin Laland in the School of Biology was awarded the British Psychological Society’s best academic book award for 2017 for his monograph, Darwin’s Unfinished Symphony:How Culture Made the Human Mind.

Drawing on his own groundbreaking research, Professor Laland’s book traces our rise from scavenger apes in prehistory to modern humans able to design iPhones, dance the tango, and send astronauts into space. The book describes how our species’ extraordinary capacity for cultural production, from the arts and language to science and technology, evolved from its animal roots. According to Laland, our culture is not only a magnificent end product of the evolutionary process, but was also a key driving force behind it. The truly unique characteristics of our species – our intelligence, language, teaching, and cooperation – are not adaptive responses to predators, disease or other external factors: rather, humans are creatures of their own making.

Professor Laland presented his book to huge crowds at this year’s Hay Book Festival. In a whistle-stop tour through three decades of research, Laland describes how investigations of animal behavior – from painting elephants to dancing cockatoos – sheds light on human origins. Animals imitate, innovate, and have remarkable traditions of their own. New scientific findings suggest that such learned and socially transmitted activities amongst our ancestors shaped our intellects through accelerating cycles of evolutionary feedback. Darwin’s Unfinished Symphony tells the story of the key advances, the false leads, and the scientific breakthroughs that led to a new understanding of how culture transformed human evolution, to generate a species unlike all others.

Wednesday, 8 February 2017

International Day of Women and Girls in Science

The University will mark the UN’s International Day of Women and Girls in Science this week with an inaugural lecture by renowned British geneticist Dame Professor Linda Partridge.

Professor Partridge, who is co-founder of the Max Planck Institute for Biology and a member of the Institute of Healthy Ageing at University College London, will deliver a public lecture entitled “Ageing Healthily” at 1pm on Friday, 10 Februaryn 2017, in the Byre Theatre.

To mark the occasion, we asked some of our leading female scientists what inspires them and what advice they would give to females and young girls looking to pursue a career in science. You can join in the conversation on social media using the hashtag #IntlDayofWomenGirlsinScience – please also tag @univofstandrews so we can retweet! 

Dr Sascha Hooker, Reader, School of Biology 

Sascha is a marine ecologist at the Sea Mammal Research Unit. Sascha has been involved in research into the ecology and conservation of marine mammals since 1993. She has three main areas of research: the interaction between marine mammal behaviour and the surrounding environment, the physiological mechanisms underpinning diving behavior, and the application of these to conservation planning in the ocean. She completed her undergraduate research in Zoology with Anthropology at the University of Oxford, then did her PhD research at Dalhousie University, Canada, where she studied the foraging ecology of northern bottlenose whales in eastern Canada, completing this in 1999. She held a post-doctoral fellowship at the British Antarctic Survey working on Antarctic fur seal foraging in South Georgia, and a UK Royal Society Dorothy Hodgkin Fellowship (2003-2010) at St Andrews working more generally on marine mammal foraging strategies. She has reduced her hours to a half-time position since 2004 when she had the first of her three children.

What was your childhood ambition? 
I grew up with the first NASA space shuttle expeditions and Carl Sagan’s book Cosmos dominated my imagination as a child. I loved the idea of being an explorer.

What inspired you to get involved in Marine Biology? 
In fact, my A-level choices were maths, chemistry and physics, and I thought I would be a chemist. It was only when I became involved in scuba diving that I realised just how amazing the ocean was. Involvement in a university conservation expedition cemented my desire to work in marine conservation. My PhD was spent looking at the ecology and conservation of a relatively unknown whale – the northern bottlenose whale.

Who are your scientific heroes? 
Sir Joseph Hooker (an eminent botanist and friend of Charles Darwin’s) was actually my great-great-grandfather, and he is a bit of a hero. He was involved in botanical expeditions all over the world and was the ‘founder of geographical botany'. Many plants and even a sea lion in New Zealand bear the name ‘hookeri’. On my way to South Georgia to work on the fur seals there, I even got to stand on ‘Hooker’s Point’ in the Falkland Islands, presumably named after him when the James Clark Ross expedition that he was part of stopped there for the winter!

What is the most rewarding part of your job?
The ability to keep challenging yourself is one of the greatest parts of this job. This job is amazingly diverse: I love research and the finding out of the previously unknown, but teaching, and even our administrative duties can keep us on our toes. So we are constantly challenged in terms of new ideas, new studies, new fieldwork, learning new analysis tools, making our results available to others, teaching students and even inspiring school kids. I have become particularly interested in some of the new technologies we can use to study marine mammals – from my PhD spent trying to attach dataloggers to northern bottlenose whales, to my work looking at prototype oceanographic and digital camera tags on Antarctic fur seals.

What advice would you give to females and young girls who may be interested in pursuing a career in your field?
Go for it. Follow your passion. There are many more opportunities these days than in the past – embrace them.

Dr Tracey Gloster, Wellcome Trust Research Fellow, School of Biology 
Tracey completed her undergraduate Bsc (Hons) degree in Biochemistry at the University of Warwick, and subsequently went on to undertake a PhD in biochemistry/structural biology at the University of York under the supervision of Professor Gideon Davies. Following this she spent a short period working as a postdoctoral fellow in York, before being awarded a Sir Henry Wellcome Postdoctoral Fellowship by the Wellcome Trust. Tracey spent the majority of this fellowship at Simon Fraser University, Canada, working under the mentorship of Professor David Vocadlo. Tracey returned to the UK in 2012 with a Wellcome Trust Research Career Development Fellowship which she holds at the University of St Andrews. Tracey was awarded a Biochemical Society Early Career Research award in 2012, a L’Oreal Fellowship for Women in Science in 2013, and was elected to the Young Academy of Scotland in 2016.

 What was your childhood ambition? 
To be honest I can’t remember if I ever really had an ambition! I always liked science and maths subjects at school, and at one point wanted to be an accountant or statistician. While taking my GCSEs the love of science took hold and I knew I wanted to study the science subjects in more depth. I don’t think I ever had the ambition to specifically be a research scientist at a university, primarily because I wasn’t aware this career existed when I was younger.

What inspired you to get involved in biochemistry? 
I enjoyed both biology and chemistry subjects at GCSE and A-level, but what I found most interesting and exciting was when we learnt about the underlying chemistry in biological processes. I found understanding complex processes such as how we generate energy from the food we eat or how plants harness energy from the sun in order to sustain life fascinating, and so I decided to pursue a degree in biochemistry when I went to university.

Who are your scientific heroes? 
It has to be some of the iconic females that have been very successful in my area of science in an era when the science world was greatly dominated by males. One of these is Rosalind Franklin who played a pivotal role in discovering the structure of DNA, but unfortunately passed away before the real importance of her work was recognised, and didn’t receive a Nobel Prize alongside others for the work. Secondly, Dorothy Hodgkin, who was awarded a Nobel prize for elucidating the structure of vitamin B12. She later went on to solve the structure of insulin, which took decades of effort and was a real tour de force in protein crystallography at the time, and subsequently influenced treatments for diabetic patients. The third hero is Eleanor Dodson, who was a mentor to me during my time at the University of York and an inspirational lady. She in now in her 80s but still active in the field of crystallography. She has incredible determination and could work things out where many people had already given up.

What is the most rewarding part of your job? 
I think it’s the excitement of seeing a good result from a scientific experiment for the first time, and the thought that even for a few moments you’re the only person in the world that knows something. Even if it is a minor breakthrough, it gives the encouragement to do follow up experiments, and gives hope that the findings may have a real impact in the longer term.

What advice would you give to females and young girls who may be interested in pursuing a career in your field? 
Give it a go! Whether male or female you should do what you enjoy and interests you most, your gender shouldn’t matter. Work hard at school, and if possible try to get some work experience in a research laboratory so you can get a taste for what it involves.

Dr Cat Hobaiter, Lecturer, School of Psychology & Neuroscience 
Cat studies the evolution of communication and social behaviour, in particular through long-term field studies of wild chimpanzees. During her PhD she conducted the first systematic study of gestural communication in a wild ape, working in the Budongo Forest Reserve in Uganda with the Sonso chimpanzee community. Like humans, apes do not gesture or vocalise in isolation - their communication combines calls, gestures, facial expressions, and body postures; in order to better understand their communication and cognition Cat and her fellow researchers have integrated the study of all of these separate modalities into a single study of communication. Through this work Cat hopes not only to advance our understanding of great ape communication but also by looking at areas of overlap or species specific traits, they hope to gain an understanding of the evolutionary origins of language.
In addition to this work Cat studies the acquisition and flexibility of social behaviour. She has recently set up the habituation of a new neighbouring community at the Budongo Conservation Field Station, looking at the effect of female immigration on their behavioural repertoires.

What was your childhood ambition? 
I always loved exploration and adventure, I travelled a lot and read everything I could get my hands on from space-travel to adventures under the sea or in the Amazon.

What inspired you to get involved in field primatology? 
I’d learned about evolutionary theory in school, but it was only in my undergrad degree that I discovered we could apply evolutionary theory to how our minds developed. We can trace not just bones and fossils, but behaviour - speech, culture, tool use - back through evolutionary time! Not long after I was lucky enough to go out to the field for the first time to study baboon ecology. I got my first glimpse of how complex, subtle, and fascinating primate society was, combine that with getting to live and work in an incredible rainforest and I was hooked!

Who are your scientific heroes? 
That’s a tough one! I’m constantly in awe of the level of detail and insight shown in the early studies of wild apes by people like Jane Goodall, Toshisada Nishida, or George Schaller. I can’t count how many times I think I’ve seen something new, only to find a careful note on it in one of their books from 50 years ago! Then there are the pioneers of ape behavioural research who are still out there showing us how it’s done properly, and still excited and passionate about what they do, people like Wrangham, Mitani, and Matsuzawa. And I’ve been incredibly lucky to be supervised and mentored by Dick Byrne at St Andrews, whose work on deception, imitation, and communication has changed how we see ape cognition, and who taught me to look for the patterns in behaviour that clue us in to primate minds.

What is the most rewarding part of your job? 
Field work with wild apes sounds exciting and exotic, but a lot of it is waking up at 5am to walk 20km crawling through rainforest thicket, with ants in your socks and not a chimp in sight. The plus side of that is that you get to spend the day crawling through a rainforest - so there’s always something to see! And I get to watch and study wild chimpanzees living their lives - whether that’s the big exciting stuff like hunting for monkeys or fighting with the neighbours, or the subtle changes in who sits next to whom, that seem completely innocuous but that represent the first steps toward a coup-d’etatat that will topple the whole male hierarchy. I’m very lucky that I’ve been able to work with the chimps in Budongo for 12 years. I’ve be able to see the little kids I met when I first came grow up to have kids of their own, it's been the most incredible privilege to study their lives unfolding. Every day is a little different, and every day I learn something new about them. I also really enjoy the data analysis - getting to tease out the patterns in the data and see the picture of the behaviour start to unfold after years of work is immensely satisfying.

What advice would you give to females and young girls who may be interested in pursuing a career in your field? 
The most important thing is to do whatever makes you excited to get out of bed in the morning (even if it’s 5am..!). If you think that might be field primatology then at some point it’s a great idea to get some experience and make sure it’s for you before you find yourself in a remote forest with a return ticket in 12months. Field-time of any kind is a big help, even if it’s not specifically primates yet, get outside somewhere and get stuck in - somewhere where you have to watch and wait, and where when nothing goes to plan you need to think up a new one. If you’re looking at universities, look for schools that have links to active field sites (St Andrews is one!), and try to do an undergrad or masters that will give you field experience. If you’re not sure you want to go down the academic route but love the idea of primate fieldwork then there are jobs as field-site managers and in conservation organisations - but they will probably still want you to have some field experience, so you might need to think about working as a volunteer or intern for a stint first.

Dr Maggie Ellis, Dementia Fellow, School of Psychology and Neuroscience 

Maggie’s research interests lie in the psychology of dementia where cognitive and social perspectives meet, with a focus on the communication difficulties experienced by people with dementia and those who care for them. Maggie is particularly interested in the interplay between the cognitive and social impact of dementia on personhood and the self of individuals with dementia.

What was your childhood ambition?
I wanted to be a journalist. One of my primary school teachers encouraged me as she thought I had a gift for story composition.

What inspired you to get involved in Psychology, and particularly dementia? 
I was aiming to get into clinical psychology and realised very quickly that I needed some volunteering work on my CV. I began volunteering for Alzheimer Scotland at their local day and evening care services and loved it so much that my whole career trajectory shifted.

Who are your scientific heroes? 
I have two main scientific heroes. Professor Tom Kitwood and Professor Steven Sabat. They both transformed the way we view dementia and those living with the condition.

What is the most rewarding part of your job? 
Engaging with individuals with advanced dementia who have lost the ability to speak and helping their family members and caregivers to connect with them.

What advice would you give to females and young girls who may be interested in pursuing a career in your field? 
My main piece of advice would be to volunteer for a dementia charity or day care service. This helped me immensely in terms of attaining hands-on experience and knowledge of dementia from a non-scientific perspective.

These days twitter is a great online resource for finding out more about specialist areas in science, and a fantastic way to broaden out who you can talk science with. A lot of the primate community is active on twitter, and you can find out what everyone thinks about the latest paper or hear about job and research opportunities as they come up.

Thursday, 8 October 2015

Sea Mammals and Sonar Symposium: 27-28 October

Concern over the increasing levels of anthropogenic sound in the ocean has existed for several decades. Research undertaken to understand the impacts of this include Behavioural Response Studies (BRS), which focus mainly on the response of marine mammals to anthropogenic sounds.

Researchers in the field and other stakeholders (e.g. navy, regulators, NGO, industry) are invited to this free two-day symposium to be held at the University of St Andrews, which will address the progress in the field of understanding the impact of anthropogenic sound in the ocean. The results of the Sea Mammals and Sonar Safety (3S) project will be presented, as wella as the results from related research projects. There will be ample time for discussion focusing on future research needs and opportunities. Input from scientists, NGOs, industry and regulators is aimed for.

The symposium is free of charge, but registration is required for logistical reasons. For more informatio and to register, please follow the symposium link.

Friday, 4 September 2015

African vultures declining at a critical rate

"Nobody liked vultures much until now, but the change isn’t good news. Big birds appear to be next on the hunters’ list for the bushmeat trade, and vultures are their new favourite.

Researchers visited hundreds of bushmeat stalls at 67 markets in 12 countries across West and Central Africa, and found 52 species of vultures and other raptors for sale. More than a quarter of them are classified as near threatened, vulnerable or endangered on the International Union for Conservation of Nature’s Red List.

Team member Ralph Buij of Wageningen University in the Netherlands estimates that more than 6000 of these birds are traded across West Africa alone each year, including around a thousand endangered hooded vultures.

The numbers may not sound huge, but Buij says that the trade represents “a sizeable proportion” of the populations of some species. The team estimates that 5 to 8 per cent of West Africa’s 450 or so white-headed vultures end up on meat stalls each year, for instance."

"Vultures play a vital role in clearing up carcasses of wild animals and livestock, suppressing the transmission of diseases to humans via mammal scavengers such as dogs,” says Phil Shaw of the University of St Andrews in the UK."

Above extracts taken from Vultures are new target for African bushmeat and medicine trade' in the New Scientist  1st September 2015

[Press Release]
Study by Shaw et al.: Conservation Letters, DOI: 10.1111/conl.12182

Monday, 1 December 2014

The Building Blocks of Life

Searching for the essence of life on Earth, understanding climate change and investigating the spread of diseases - these are a few examples of the fundamental research that academics at St Andrews will be tackling with new equipment won under a competitive £0.5M NERC grant! This cutting edge analytical set-up combines a multi-collector inductively coupled plasma mass spectrometer (MC-ICP-MS) with a gas chromatograph (GC), and will be the first of its kind in the EU (and only the third in the world!). The NERC capital equipment fund bid was led by Drs Andrea Burke, James Rae, and Heidi Burdett from the Department of Earth and Environmental Sciences, supported by an interdisciplinary team including Profs David PatersonIan Johnston, and Derek Woollins from the Schools of Biology and Chemistry.
 
The state-of-the-art clean mass spectrometry lab where the new
equipment will be housed
One of the exciting major applications for this new equipment is the measurement of sulfur isotopes. The study of sulfur has both pure and applied uses, as it is a key element on scales ranging from nano to global, and in processes ranging from climate forcing by volcanic eruptions, to the processing of sulfur-rich crude oils. This new analytical set-up permits the measurement of sulfur isotopes on samples a thousand times smaller than previously possible, and will provide valuable new information on climate sensitivity, metabolic pathways, and Earth resources and their recovery.

 For further information on this, contact Dr Andrea Burke.

Friday, 3 October 2014

Interior designing birds

Researchers from  the the School of Biology have produced the first experimental evidence that birds actively select nest-building materials that camouflage their nests.

Dr Ida Bailey, Felicity Muth, Drs Kate Morgan and Susan Healy wallpapered male zebra finches’ (Taeniopygia guttata) cages in different colours and then filmed them choosing the colour of material with which to build their nests. Given two different coloured paper strips from which to choose, the zebra finches largely chose strips that were a colour-match to the paper covering the walls of their cage.

These findings confirm that birds choose to camouflage their nests by matching the colour of material they use to the nests' background, rather than happening to build camouflaged nests as a simple consequence of the materials that are available.

Research article DOI: http://dx.doi.org/10.1642/AUK-14-77.1 [Press release]

Friday, 29 August 2014

Two St Andrews scientists to receive Wolfson Research Merit Awards

Prof. Malcolm White
Two leading scientists from the University of St Andrews are to receive Wolfson Research Merit Awards from the Royal Society. ‌ Professor Malcolm White (School of Biology) and Professor Sven Hoefling (School of Physics and Astronomy) are named in an exclusive, recently published list of only14 outstanding UK scientists to receive the honour.

Prof. Sven Hoeling
Professor White’s award, the CRISPR-Cas system for prokaryotic antiviral defence, recognises his research into a recently discovered immune system in microbes. His work is aimed at understanding how these complex molecular machines detect and destroy invading viruses.

Professor Hoefling's award, Quantum engineered semiconducting and transition metal oxide materials, is in appreciation of his work to understand and exploit light-matter interactions.

Jointly funded by the Wolfson Foundation and the Department for Business, Innovation and Skills (BIS), the scheme aims to provide universities with additional support to enable them to attract science talent from overseas and retain respected UK scientists of outstanding achievement and potential.
[press release]

Monday, 25 August 2014

New at St Andrews: Institute for Data-Intensive Research

The St Andrews Institute for Data-Intensive Research (IDIR) is a new institute set up to provide a focus for research and teaching activities across the University driven by access to “big data”. 

IDIR will bring the University’s strengths in humanities and social sciences with those in computer, mathematical, life, and physical scientists to share insights and techniques. IDIR results from the enormous volume of activity taking place across the University that could broadly be described as data-driven – from data science, through digital humanities and digital social science, to digital medicine, which all share common characteristics. They are exploring new techniques and opportunities brought about by the availability of large volumes of data and the processing power needed to manipulate them.

Some of the Schools included are Computer Science, Mathematics & Statistics, Physics & Astronomy, Medicine, Chemistry, Biology, International Relations, Earth and Environmental Sciences and History.

Tuesday, 17 June 2014

Silencing of the crickets: rapid evolution in response to deadly flies

Scientists in the School of Biology, along with researchers from Edinburgh and the USA, have have published a new study on the rapid evolution of wild crickets from predominantly loud, chirping males to silent males in approximately one decade on two islands in Hawaii. Typically, male crickets attract females with their songs by rubbing their wings, which have a sound-producing file and scraper, together. However, parasitic flies use the sound of male songs to find the crickets and deposit baby maggots on their backs. The maggots burrow in and eat the crickets alive as they grow.

Some male crickets in Hawaii have silenced their songs because of a mutation that erases the file and scraper on their wings. Interestingly, these ‘flatwing’ mutations have happened independently, about two years apart, on both the islands of Kauai and Oahu. This convergent evolution is rarely observed at such evolutionary speed in the wild and is an excellent opportunity to look at this phenomenon in its earliest stages. The team, including Dr Sonia Pascoal, Prof. Michael Ritchie, and Dr Nathan Bailey, next hope to identify the mutations responsible for the changes.
[Full article: http://dx.doi.org/10.1016/j.cub.2014.04.053]BBC News story]

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Thursday, 17 April 2014

Bird-brain DIY: Birds learn from experience when building nests

It is typically assumed that it is a bird’s genes that cause it to choose the materials with which it builds its nest. To test this assumption, Dr Susan Healy and others from the School of Biology investigated whether learning plays a role in these decisions, specifically with regard to whether birds learn the physical properties of the materials they use in nest building.

A nest built with
more flexible string
In their experiments, zebra finches were given lengths of string that were either relatively stiff or relatively flexible. Once the birds had had some experience of building with their allocated string type, the researchers gave them a choice of both types of string. They observed that those zebra finches that had experienced building with the more flexible sort of string preferred to build with the stiffer string, whereas those birds that had experienced only the stiffer string were less choosy. We also saw that the birds that built nests using the stiffer string required many fewer (about 400) pieces to construct a typical zebra finch nest than did the birds that built a nest with the more flexible string (about 700 pieces). This indicates two things: (1) the stiffer string was the more effective nest building material and, (2) the birds readily learned to avoid the poorer building material.
A nest built with
more stiff string

If birds’ nest-material decisions had been entirely based on their genes, then their prior building experience should not have affected their decisions. That it did shows that learning about what materials work best is important in the decisions made by nest-building birds, much as it is important to people deciding what materials or tools to use for craft or DIY projects. In the wild this ability might allow birds to choose the most suitable material available, allowing them to respond flexibly to the habitat in which they are nesting.

The study, Physical cognition: birds learn the structural efficacy of nest material, is published in the Proceedings of the Royal Society - B.

Wednesday, 9 April 2014

Novel microscope for biological imaging

A new form of ‘light sheet imaging’, has been developed by an interdisciplinary team led by Professor Kishan Dholakia and Dr Tom Vettenburg of the School of Physics. A light sheet microscope creates 3D images of cells by seeing how a sample lights up slice-by-slice when moved through a sheet of light. This sheet would ideally be as thin as a razor’s edge to be able to probe the inner workings of all cells, yet gentle as light to avoid cell damage. The St Andrews group achieved this by exploiting a beam of light that moves on a peculiarly curved trajectory. The beam is known as the Airy beam after the British astronomer Sir George Airy consists of multiple parallel sheets of light, achieving high resolution without being thin. Using this method, the light is used more efficiently to see the inner details of hundreds of cells with clarity.

It is hoped that the development will lead to improved understanding of biological development, cancer, and diseases such as Alzheimer, Parkinson, and Huntington that affect the human brain.
Partners are sought for the commercialization of the technology.

The work was funded by a UK EPSRC Programme Grant and carried out with St Andrews colleagues Dr Heather Dalgarno and Jonathan Nylk (School of Physics & Astronomy), Dr David Ferrier and Clara Coll-Lladó (Scottish Oceans Institute), Dr Tomáš Cižmár (School of Medicine), and Professor Frank Gunn-Moore (School of Biology).
Nature Methods, "Light-sheet microscopy using an Airy beam", doi:10.1038/nmeth.2922

Tuesday, 10 December 2013

The genetic 'tug-of-war' of menopause

The menopause, and its turbulent transition, can be blamed on a conflict between the genes a woman inherits from each of her parents, according to Dr Andy Gardner of the School of Biology and scientists at Royal Holloway, University of London and Sokendai Graduate University for Advanced Studies in Japan. One set of genes wants her to continue having children while the other wants her to stop. There is a possibility that the genes underpinning menopause are epigenetically regulated can help researchers identify genetic markers for associated disorders, such as cardiovascular disease and certain cancers. The research also suggests novel applications in family planning, personalised according to a woman’s genetic background.

The study, which will appear in the February issue of the journal Ecology Letters, informs the development of personalised family planning and preventative medicine strategies for dealing with cardiovascular problems – and even some cancers. [press release]

Thursday, 25 July 2013

Ocean acidification takes the bite out of foraminifera

Rising carbon dioxide levels in the atmosphere are having a catastrophic effect on microscopic marine life, according to marine scientists in the School of Biology. Experiments show microscopic organisms, called foraminifera (‘forams’), suffer the equivalent of tooth-decay as seawater becomes more acidic. Since ‘forams’ may number 500,000 in a square meter of sediment, other organisms further up the food chain are also likely to be affected by these changes. The findings will be presented at the 3rd annual meeting of the UK Ocean Acidification Research programme being hosted by the University of St Andrews, Scotland on 24 July 2013. [press release]
Full progamme of the Live webcast of joint UKOA / GOA-ON session

Wednesday, 20 March 2013

Company launched with aim to improve fish quality

A new company, which aims to exploit cutting-edge genetics technology to improve the quality of the fish we eat, has been launched in St Andrews. With support from local law firm Murray Donald and the Biotechnological and Biological Research Council (BBSRC), Xelect, is primarily focusing on the development of genetic markers which will pinpoint the most valuable of the natural variations which occur in all fish. Xelect was formed by CEO and Co-Founder Professor Ian Johnston, Director, Scottish Oceans Institute and his former PhD student, Thomas Ashton, Executive Director and Co-Founder. The first products are markers for superior meat yield and flesh quality in Atlantic salmon, which are now available for licensing worldwide. [press release] [more..]

Monday, 18 March 2013

5 University of St Andrews RSE Young Academy members announced

The Royal Society of Edinburgh (RSE) has announced the second group of RSE Young Academy of Scotland appointments, which consists of 50 new members, including 5 from St Andrews.
The RSE Young Academy of Scotland fosters interdisciplinary activities among emerging leaders from the disciplines of science and humanities, the professions, the arts, business and civil society. Established by the Royal Society of Edinburgh in 2011, the Young Academy of Scotland provides a platform for able and innovative young entrepreneurs, professionals and academics to develop a coherent and influential voice, and to address the most challenging issues facing society in Scotland and beyond.

Tuesday, 20 November 2012

£5.6m project seeks new Foot and Mouth vaccine

A £5.6 million Biotechnology and Biological Sciences Research Council (BBSRC) funded research project, led by Professor Martin Ryan of the School of Biology, aims to find a new vaccine to combat Foot and Mouth Disease in livestock. The 5-year study, which will also involve the Pirbright Institute, and the Universities of Dundee, Edinburgh and Leeds will investigate how the virus grows in, and interacts with, cells to harness such knowledge to improve diagnosis and develop a new generation of more effective vaccines.

The Foot and Mouth Disease Virus (FMDV) is one of the most contagious viruses in domestic livestock including cattle, sheep, goats and pigs and can infect more than 70 species of wildlife, greatly increasing the difficulty of disease control, which is further complicated by the existence of seven distinct serotypes with thousands of strains of the virus.

Outbreaks of FMDV in the UK in 2001 and 2007 had devastating effects on farming. The 2001 outbreak cost the UK economy billions of pounds with millions of animals destroyed. [press release]

Wednesday, 19 September 2012

Chair of AIG for NERC Omic programme announced

Professor Thomas Meagher of the School of Biology has recently been appointed as Chair of the Advisory & Implementation Group (AIG) for the NERC Thematic Programme on Mathematics & Informatics for Environmental Omic Data Synthesis, a five-year research programme to the fundamental knowledge needed to integrate large volumes of genomic, transcriptomic, proteomic and metabolomic data into wider environmental analyses to address new research questions. A major goal of the programme is to promote the development of omic informatics as a professional niche within environmental research via various funding schemes, including discipline-hopping to and from mathematical and computational sciences. NERC has allocated £4m to this programme.

Tuesday, 18 September 2012

Hyenas are innovative problem solvers

New research by Dr Sarah Benson-Amram of the School of Biology and Dr Kay Holekamp of Michigan State University has shown that spotted hyenas (Crocuta crocuta) are adept at problem solving and may even be able to “count”, demonstrating that the animals may have the intelligence levels of some primates.

The team presented wild spotted hyenas with a large steel puzzle box with meat inside. In order to get the meat, the hyenas had to slide open a bolt latch. The team measured the hyenas' reluctance to approach the puzzle box and the number of tactical behaviours that they used to try to open it, as well as their persistence. The researchers demonstrated that the hyenas, whether adult or juvenile, that quickly contacted the puzzle box when they first saw it and that exhibited a greater diversity of exploratory behaviours were more successful problem solvers. [full article]

Additionally, in a previous study, the researchers played calls simulating 1, 2, or 3 territorial intruders to hyenas in groups of varying sizes and found that hyenas assess the size of a competing pack before engaging in aggressive encounters. They will only confront the intruders if the “count” shows they have a numerical advantage. [full article]

Thursday, 26 July 2012

Amphioxus provide new insights to causes of human diseases

Newly published research from Dr David Ferrier of the School of Biology and scientists at the University of Dundee, suggests that an evolutionary leap made at the bottom of the ocean over 500 million years ago could give new insights into the causes of human diseases such as diabetes, cancer and neurological disorders.

Vertebrates emerged around 500 million years ago from a massive evolutionary upheaval that involved two successive doublings in the amount of DNA in a marine invertebrate. These dramatic events triggered the evolution of a new animal, which became the ancestor of the backboned fishes, birds, reptiles and mammals, including humans.

 

The research proposes that these ancient DNA doublings boosted internal communication systems. The result is that cells in our bodies are far better at integrating information than even the smartest smartphones. Such complexity is needed to coordinate the actions of our elaborate human bodies. The downside is that communication breakdowns cause diabetes, cancer and neurological disorders. Researchers have been able to compare the human genome to the recently decoded genetic sequence of the invertebrate amphioxus, a tiny creature still found in our seas and which can be regarded as a 'distant cousin’ to our species. The ancestors of amphioxus did not go through the two rounds of genome duplication and so is still quite similar to the original spineless creature.

According to Dr Ferrier, “Amphioxus is proving to be an excellent animal with which to understand various aspects of the evolution of vertebrate genomes, including the human genome. This is particularly true for families of genes that increased in size and complexity during vertebrate evolution. “Analysis of these gene families from an evolutionary point of view helps to navigate through the increasingly large data sets on protein interactions in a more focused and productive way, speeding the way towards establishing the links between particular proteins and diseases as well as highlighting new potential disease targets." [full article][press release]

Thursday, 28 June 2012

St Andrews scientists make breakthrough in 'floppy baby' syndrome

A team led by Dr Judith Sleeman of the School of Biology has made advances in the understanding of the inherited motor neurone disease, Spinal Muscular Atrophy (SMA), also known as 'floppy baby' syndrome. The condition is the leading genetic cause of death in children and affects one in 6000 live births. Using cell culture models of SMA, the team have uncovered differences in the movement of key parts of a molecular 'machine', the spliceosome, which is vital to the way genes work by helping to decode the DNA molecules carrying genetic instructions and removing unneeded sections. In conditions such as SMA, this decoding process goes wrong.  [press release] [Clelland et al., 2012]

Splicing factors (red), vital parts of the molecular machine needed to decode the cell's genetic information, in the nuclei of human cells (Clelland et al., 2012).
Further information and support advice for families affected by SMA is available from the Jennifer Trust for Spinal Muscular Atrophy.